Cargando…

Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?

BACKGROUND: Several c-MET targeting inhibitory molecules have already shown promising results in the treatment of patients with Non-small Cell Lung Cancer (NSCLC). Combination of EGFR- and c-MET-specific molecules may overcome EGFR tyrosine kinase inhibitor (TKI) resistance. The aim of this study wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watermann, I., Schmitt, B., Stellmacher, F., Müller, J., Gaber, R., Kugler, Ch., Reinmuth, N., Huber, R. M., Thomas, M., Zabel, P., Rabe, K. F., Jonigk, D., Warth, A., Vollmer, E., Reck, M., Goldmann, T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517562/ https://www.ncbi.nlm.nih.gov/pubmed/26215852 http://dx.doi.org/10.1186/s13000-015-0362-5

Ejemplares similares

Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC
por: Gaber, Rania, et al.
Publicado: (2014)

Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas
por: Pasternack, Helen, et al.
Publicado: (2021)

LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplification
por: Lang, Dagmar S, et al.
Publicado: (2008)

Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung
por: Schultz, H, et al.
Publicado: (2011)

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
por: Goldmann, Torsten, et al.
Publicado: (2018)

Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy
por: Nitschkowski, Dörte, et al.
Publicado: (2019)

Fountain of youth for squamous cell carcinomas? On the epigenetic age of non‐small cell lung cancer and corresponding tumor‐free lung tissues
por: Marwitz, Sebastian, et al.
Publicado: (2018)

On the significance of Surfactant Protein-A within the human lungs
por: Goldmann, Torsten, et al.
Publicado: (2009)

DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer
por: Goldmann, Torsten, et al.
Publicado: (2021)

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer
por: Oddo, Daniele, et al.
Publicado: (2017)

MET Amplification and Efficacy of Nivolumab in Patients With NSCLC
por: Yoshimura, Katsuhiro, et al.
Publicado: (2021)

Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema
por: Eggers, Lars F., et al.
Publicado: (2017)

MET nucleotide variations and amplification in advanced ovarian cancer: characteristics and outcomes with c-Met inhibitors
por: Tang, Chad, et al.
Publicado: (2013)

MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors
por: Peng, Lun-Xi, et al.
Publicado: (2021)

Correlation of MET-Receptor Overexpression with MET Gene Amplification and Patient Outcome in Malignant Mesothelioma
por: Santoni-Rugiu, Eric, et al.
Publicado: (2021)

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization
por: Schmitt, Christina, et al.
Publicado: (2021)

Targeting MET Amplification as a New Oncogenic Driver
por: Kawakami, Hisato, et al.
Publicado: (2014)

Targeting MET Amplification: Opportunities and Obstacles in Therapeutic Approaches
por: Kumaki, Yuichi, et al.
Publicado: (2023)

Efficacy and Tolerability of ALK/MET Combinations in Patients With ALK-Rearranged Lung Cancer With Acquired MET Amplification: A Retrospective Analysis
por: Dagogo-Jack, Ibiayi, et al.
Publicado: (2023)

Evolution of MET and NRAS gene amplification as acquired resistance mechanisms in EGFR mutant NSCLC
por: Peters, T. L., et al.
Publicado: (2021)

A case report of response to crizotinib in chemotherapy-refractory metastatic gallbladder cancer with met amplification and acquired resistance resulting from the loss of MET amplification
por: Sun, Hongna, et al.
Publicado: (2021)

MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC
por: Tyler, Logan C., et al.
Publicado: (2022)

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification
por: Wang, Jieyi, et al.
Publicado: (2016)

MET amplification as a potential therapeutic target in gastric cancer
por: Kawakami, Hisato, et al.
Publicado: (2012)

Effect of low tidal volume ventilation on lung function and inflammation in mice
por: Hauber, Hans P, et al.
Publicado: (2010)

Comparison of the effect of lps and pam3 on ventilated lungs
por: Hauber, Hans P, et al.
Publicado: (2010)

Correction: effect of low tidal ventilation on lung function and inflammation in mice
por: Hauber, Hans P, et al.
Publicado: (2012)

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells
por: Presutti, Dario, et al.
Publicado: (2015)

Using Citizen Science to examine health and access to health care of uninsured patients in Germany
por: Warth, J, et al.
Publicado: (2022)

MET Inhibitor is Expected to Overcome MET Amplification-Induced Immunotherapy Resistance in Non-Small Cell Lung Cancer
por: Ruan, Ji
Publicado: (2021)

Comparison of in situ and extraction-based methods for the detection of MET amplifications in solid tumors
por: Heydt, Carina, et al.
Publicado: (2019)

TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens
por: Schultz, Holger, et al.
Publicado: (2008)

MET overexpression, gene amplification and relevant clinicopathological features in gastric adenocarcinoma
por: Zhang, Jing, et al.
Publicado: (2016)

Optimal Treatments for NSCLC Patients Harboring Primary or Acquired MET Amplification
por: Sun, Dantong, et al.
Publicado: (2022)

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression
por: Marwitz, Sebastian, et al.
Publicado: (2017)

Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer
por: Marwitz, Sebastian, et al.
Publicado: (2021)

Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology)
por: Kayser, Klaus, et al.
Publicado: (2008)

Prognosis and Concurrent Genomic Alterations in Patients With Advanced NSCLC Harboring MET Amplification or MET Exon 14 Skipping Mutation Treated With MET Inhibitor: A Retrospective Study
por: Liu, Li, et al.
Publicado: (2021)

Precision medicine approaches to lung adenocarcinoma with concomitant MET and HER2 amplification
por: Oh, Doo-Yi, et al.
Publicado: (2017)

Prevalence and Clinicopathological Significance of MET Overexpression and Gene Amplification in Patients with Gallbladder Carcinoma
por: Kim, Yeseul, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k5ddrjpo58bhhc7pof8q04kme1