Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

BACKGROUND: The cytoplasmic RIG-like receptors are responsible for the early detection of viruses and other intracellular microbes by activating the innate immune response mediated by type I interferons (IFNs). RIG-I and MDA5 detect virus-specific RNA motifs with short 5′-tri/diphosphorylated, blunt...

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Detalles Bibliográficos
Autores principales: Louber, Jade, Brunel, Joanna, Uchikawa, Emiko, Cusack, Stephen, Gerlier, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517655/
https://www.ncbi.nlm.nih.gov/pubmed/26215161
http://dx.doi.org/10.1186/s12915-015-0166-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517655/
https://www.ncbi.nlm.nih.gov/pubmed/26215161
http://dx.doi.org/10.1186/s12915-015-0166-9

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