Cargando…

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation

FTO (fat mass and obesity associated gene) was genetically identified to be associated with body mass index (BMI), presumably through functional regulation of energy homeostasis. However, the cellular and molecular mechanisms by which FTO functions remain largely unknown. Using 3T3-L1 preadipocyte a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Meizi, Zhang, Ying, Ma, Jun, Guo, Feima, Cao, Qian, Zhang, Yu, Zhou, Bin, Chai, Jijie, Zhao, Wenqing, Zhao, Renbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517749/ https://www.ncbi.nlm.nih.gov/pubmed/26218273 http://dx.doi.org/10.1371/journal.pone.0133788

Ejemplares similares

m(6)A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte
por: Li, Kan, et al.
Publicado: (2022)

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers
por: Wang, Jin-yan, et al.
Publicado: (2020)

Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?
por: Mittal, Balraj, et al.
Publicado: (2016)

Genetic Associations of Obesity: The Fat-Mass and Obesity-Associated (FTO) Gene
por: Ehrlich, Adam C, et al.
Publicado: (2016)

Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)
por: Müller, Timo D., et al.
Publicado: (2013)

Comprehensive mutations analyses of FTO (fat mass and obesity-associated gene) and their effects on FTO’s substrate binding implicated in obesity
por: Kumar, Rakesh, et al.
Publicado: (2022)

Targeting the RNA demethylase FTO for cancer therapy
por: Zhou, Lin-Lin, et al.
Publicado: (2021)

Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma
por: Rong, Zhuo-Xian, et al.
Publicado: (2019)

Impact of Metabolic Regulators on the Expression of the Obesity Associated Genes FTO and NAMPT in Human Preadipocytes and Adipocytes
por: Friebe, Daniela, et al.
Publicado: (2011)

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
por: Kaklamani, Virginia, et al.
Publicado: (2011)

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm
por: Gulati, Pawan, et al.
Publicado: (2014)

Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer
por: Qin, Bo, et al.
Publicado: (2022)

FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms
por: Azzam, Sarah Kassem, et al.
Publicado: (2022)

Tissue Distribution of Porcine FTO and Its Effect on Porcine Intramuscular Preadipocytes Proliferation and Differentiation
por: Chen, Xiaoling, et al.
Publicado: (2016)

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
por: Marcinkowski, Michał, et al.
Publicado: (2021)

Relationship Between Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms with Obesity and Metabolic Syndrome in Ethnic Mongolians
por: Zhang, Qiang, et al.
Publicado: (2018)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors
por: Shishodia, Shifali, et al.
Publicado: (2021)

The Fat Mass and Obesity Associated Gene, FTO, Is Also Associated with Osteoporosis Phenotypes
por: Guo, Yan, et al.
Publicado: (2011)

Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism
por: Mizuno, Tooru M.
Publicado: (2018)

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice
por: Gao, Xue, et al.
Publicado: (2010)

Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases
por: Huang, Chaoqun, et al.
Publicado: (2022)

N (6) -methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes : ALKBH5 regulated preadipocyte proliferation and differentiation
por: Zhang, Qi, et al.
Publicado: (2021)

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
por: Li, Yue, et al.
Publicado: (2019)

The role of m(6)A demethylase FTO in chemotherapy resistance mediating acute myeloid leukemia relapse
por: Zhang, Zhi-Wei, et al.
Publicado: (2023)

Signatures of Natural Selection at the FTO (Fat Mass and Obesity Associated) Locus in Human Populations
por: Liu, Xuanshi, et al.
Publicado: (2015)

The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells
por: Relier, Sébastien, et al.
Publicado: (2022)

The biology of FTO: from nucleic acid demethylase to amino acid sensor
por: Gulati, Pawan, et al.
Publicado: (2013)

m6A demethylase FTO and osteoporosis: potential therapeutic interventions
por: Huang, Mei, et al.
Publicado: (2023)

Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test
por: Qi, Lu, et al.
Publicado: (2008)

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
por: Church, Chris, et al.
Publicado: (2009)

Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women
por: Ahmad, Tariq, et al.
Publicado: (2011)

The controversial role and therapeutic development of the m6A demethylase FTO in renal cell carcinoma
por: Zhang, Dalin, et al.
Publicado: (2022)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice
por: Sachse, Gregor, et al.
Publicado: (2018)

Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents
por: Huff, Sarah, et al.
Publicado: (2022)

Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population
por: Chang, Yi-Cheng, et al.
Publicado: (2008)

Association between rs9930506 polymorphism of the fat mass & obesity-associated (FTO) gene & onset of obesity in Polish adults
por: Wrzosek, Małgorzata, et al.
Publicado: (2016)

The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population
por: da Fonseca, Ana Carolina Proença, et al.
Publicado: (2019)

Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies
por: Elekofehinti, Olusola Olalekan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_luk196rt0apniumrom3t0eac73