Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena

The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential p...

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Detalles Bibliográficos
Autores principales: Sandoval, Pamela Y., Lee, Po-Hsuen, Meng, Xiangzhou, Kapler, Geoffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517752/
https://www.ncbi.nlm.nih.gov/pubmed/26218270
http://dx.doi.org/10.1371/journal.pgen.1005405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517752/
https://www.ncbi.nlm.nih.gov/pubmed/26218270
http://dx.doi.org/10.1371/journal.pgen.1005405

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