Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes

OBJECTIVE: Immune suppression during critical illness predisposes to serious infections. We sought to determine the mechanisms regulating tolerance and cross-tolerance to common pro-inflammatory danger signals in a model that recapitulates the intact in vivo immune response. MATERIALS AND METHODS: F...

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Detalles Bibliográficos
Autores principales: Julian, Mark W., Strange, Heather R., Ballinger, Megan N., Hotchkiss, Richard S., Papenfuss, Tracey L., Crouser, Elliott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517781/
https://www.ncbi.nlm.nih.gov/pubmed/26218271
http://dx.doi.org/10.1371/journal.pone.0132921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517781/
https://www.ncbi.nlm.nih.gov/pubmed/26218271
http://dx.doi.org/10.1371/journal.pone.0132921

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