Theme and variations: evolutionary diversification of the HET-s functional amyloid motif

In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the HET-S Helo-domain pore-forming protein by converting its prion-forming domain into a characteristic β-solenoid amyloid fold. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Daskalov, Asen, Dyrka, Witold, Saupe, Sven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518210/
https://www.ncbi.nlm.nih.gov/pubmed/26219477
http://dx.doi.org/10.1038/srep12494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518210/
https://www.ncbi.nlm.nih.gov/pubmed/26219477
http://dx.doi.org/10.1038/srep12494

Ejemplares similares