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PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabiliz...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518267/ https://www.ncbi.nlm.nih.gov/pubmed/26183061 http://dx.doi.org/10.1038/ncomms8769 |