Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens. Loss-of-function mutations that impair function of the Nox2 complex result in a life-threatening immunodeficiency, and genet...

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Detalles Bibliográficos
Autores principales: Graham, Daniel B., Becker, Christine E., Doan, Aivi, Goel, Gautam, Villablanca, Eduardo J., Knights, Dan, Mok, Amanda, Ng, Aylwin C.Y., Doench, John G., Root, David E., Clish, Clary B., Xavier, Ramnik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518307/
https://www.ncbi.nlm.nih.gov/pubmed/26194095
http://dx.doi.org/10.1038/ncomms8838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518307/
https://www.ncbi.nlm.nih.gov/pubmed/26194095
http://dx.doi.org/10.1038/ncomms8838

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