Cargando…

An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response

In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which then forms prion-like filaments and stimulates a specific signalling pathway leading to type I interferon production to restrict virus proliferation. However, the mechanisms by which MAVS activity is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Yuheng, Yuan, Bofeng, Qi, Nan, Zhu, Wenting, Su, Jingru, Li, Xiaoyan, Qi, Peipei, Zhang, Dan, Hou, Fajian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518314/ https://www.ncbi.nlm.nih.gov/pubmed/26183716 http://dx.doi.org/10.1038/ncomms8811

Ejemplares similares

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
por: Qi, Nan, et al.
Publicado: (2017)

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
por: Shi, Yuheng, et al.
Publicado: (2017)

MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis
por: Chen, Yunqiang, et al.
Publicado: (2021)

The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
por: Zhang, Rui, et al.
Publicado: (2022)

Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2014)

WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response
por: Li, Jiaxin, et al.
Publicado: (2023)

Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2015)

Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis
por: Shi, Yuheng, et al.
Publicado: (2020)

Author Correction: WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response
por: Li, Jiaxin, et al.
Publicado: (2023)

Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production
por: Qi, Shishi, et al.
Publicado: (2022)

Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response
por: Ren, Zhihua, et al.
Publicado: (2020)

SARS-CoV-2 infection and the antiviral innate immune response
por: Yang, Hui, et al.
Publicado: (2020)

TRAF5 Is a Downstream Target of MAVS in Antiviral Innate Immune Signaling
por: Tang, Eric D., et al.
Publicado: (2010)

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
por: Li, Shang-Ze, et al.
Publicado: (2019)

USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
por: Hou, Jinxiu, et al.
Publicado: (2021)

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation
por: Xu, Yan-Ran, et al.
Publicado: (2022)

Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization
por: Nobre, Luis, et al.
Publicado: (2015)

RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA
por: Zhang, Zhi-Dong, et al.
Publicado: (2020)

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
por: Li, Xingyu, et al.
Publicado: (2021)

Positive Selection Drives the Adaptive Evolution of Mitochondrial Antiviral Signaling (MAVS) Proteins-Mediating Innate Immunity in Mammals
por: Ahmad, Hafiz Ishfaq, et al.
Publicado: (2022)

Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity
por: Imamura, Ryu, et al.
Publicado: (2023)

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO
por: Wu, Jing, et al.
Publicado: (2021)

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response
por: Fu, Yu-Zhi, et al.
Publicado: (2020)

Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response
por: Nie, Ying, et al.
Publicado: (2023)

Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity
por: Zahid, Ayesha, et al.
Publicado: (2020)

Author Correction: SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
por: Li, Xingyu, et al.
Publicado: (2023)

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
por: Zhou, Peipei, et al.
Publicado: (2018)

Succinate Is a Natural Suppressor of Antiviral Immune Response by Targeting MAVS
por: Xiao, Yue, et al.
Publicado: (2022)

DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS
por: Ruan, Jie, et al.
Publicado: (2019)

CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING
por: Gokhale, Nandan S., et al.
Publicado: (2023)

Autoinhibitory Feedback Control over Photodynamic Action
por: Yurt, Mediha Nur Zafer, et al.
Publicado: (2019)

Antiviral Adaptor MAVS Promotes Murine Lupus With a B Cell Autonomous Role
por: Sun, Wenxiang, et al.
Publicado: (2019)

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation
por: Zhang, Xuewu, et al.
Publicado: (2017)

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
por: Arce, Nicholas A., et al.
Publicado: (2021)

Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains
por: Bor, Batbileg, et al.
Publicado: (2012)

IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation
por: Xia, Pengyan, et al.
Publicado: (2015)

MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity
por: Hanada, Yuki, et al.
Publicado: (2020)

Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS
por: Yang, Bo, et al.
Publicado: (2021)

Correction: GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation
por: Zhang, Xuewu, et al.
Publicado: (2018)

PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion
por: Yu, Kuai, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m2hifvmsf0khh52nkknjefkbl5