Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

Protein-protein interactions (PPIs) underlie the majority of biological processes, signaling, and disease. Approaches to modulate PPIs with small molecules have therefore attracted increasing interest over the past decade. However, there are a number of challenges inherent in developing small-molecu...

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Detalles Bibliográficos
Autores principales: Laraia, Luca, McKenzie, Grahame, Spring, David R., Venkitaraman, Ashok R., Huggins, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518475/
https://www.ncbi.nlm.nih.gov/pubmed/26091166
http://dx.doi.org/10.1016/j.chembiol.2015.04.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518475/
https://www.ncbi.nlm.nih.gov/pubmed/26091166
http://dx.doi.org/10.1016/j.chembiol.2015.04.019

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