Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that GKT137831, a dual NOX1/4 inhibitor, attenuated liver fibrosis in mice as well as pro-fibrotic genes in hepatic stellate...

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Detalles Bibliográficos
Autores principales: Lan, Tian, Kisseleva, Tatiana, Brenner, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519306/
https://www.ncbi.nlm.nih.gov/pubmed/26222337
http://dx.doi.org/10.1371/journal.pone.0129743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519306/
https://www.ncbi.nlm.nih.gov/pubmed/26222337
http://dx.doi.org/10.1371/journal.pone.0129743

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