Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

The mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body. The corresponding biochemical processes are typically subject to spatial variations at different length scales. Zonal enzyme expression along sinusoids leads to zonated metabolization already in the he...

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Detalles Bibliográficos
Autores principales: Schwen, Lars Ole, Schenk, Arne, Kreutz, Clemens, Timmer, Jens, Bartolomé Rodríguez, María Matilde, Kuepfer, Lars, Preusser, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519332/
https://www.ncbi.nlm.nih.gov/pubmed/26222615
http://dx.doi.org/10.1371/journal.pone.0133653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519332/
https://www.ncbi.nlm.nih.gov/pubmed/26222615
http://dx.doi.org/10.1371/journal.pone.0133653

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