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Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations
The mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body. The corresponding biochemical processes are typically subject to spatial variations at different length scales. Zonal enzyme expression along sinusoids leads to zonated metabolization already in the he...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519332/ https://www.ncbi.nlm.nih.gov/pubmed/26222615 http://dx.doi.org/10.1371/journal.pone.0133653 |