A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4

Early prediction of xenobiotic metabolism is essential for drug discovery and development. As the most important human drug-metabolizing enzyme, cytochrome P450 3A4 has a large active cavity and metabolizes a broad spectrum of substrates. The poor substrate specificity of CYP3A4 makes it a huge chal...

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Detalles Bibliográficos
Autores principales: Dai, Zi-Ru, Ai, Chun-Zhi, Ge, Guang-Bo, He, Yu-Qi, Wu, Jing-Jing, Wang, Jia-Yue, Man, Hui-Zi, Jia, Yan, Yang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519866/
https://www.ncbi.nlm.nih.gov/pubmed/26133240
http://dx.doi.org/10.3390/ijms160714677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519866/
https://www.ncbi.nlm.nih.gov/pubmed/26133240
http://dx.doi.org/10.3390/ijms160714677

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