Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. They are characterized by gain of function mutations in KIT or PDGFRA tyrosine kinase receptors, with their consequent constitutive activation. The gold standard therapy is imatinib that offe...

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Detalles Bibliográficos
Autores principales: Ravegnini, Gloria, Nannini, Margherita, Sammarini, Giulia, Astolfi, Annalisa, Biasco, Guido, Pantaleo, Maria A., Hrelia, Patrizia, Angelini, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519915/
https://www.ncbi.nlm.nih.gov/pubmed/26184165
http://dx.doi.org/10.3390/ijms160715592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519915/
https://www.ncbi.nlm.nih.gov/pubmed/26184165
http://dx.doi.org/10.3390/ijms160715592

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