Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis

As a ubiquitin-like modifier, ISG15 is conjugated to many cellular proteins in a process termed protein ISGylation. However, the crosstalk between protein ISGylation and the ubiquitin proteasome system is not fully understood. Here, we report that cellular ubiquitin is a substrate of ISG15 and Lys 2...

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Detalles Bibliográficos
Autores principales: Fan, Jun-Bao, Arimoto, Kei-lchiro, Motamedchaboki, Khatereh, Yan, Ming, Wolf, Dieter A., Zhang, Dong-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520236/
https://www.ncbi.nlm.nih.gov/pubmed/26226047
http://dx.doi.org/10.1038/srep12704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520236/
https://www.ncbi.nlm.nih.gov/pubmed/26226047
http://dx.doi.org/10.1038/srep12704

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