The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

Increased osteoclast-mediated bone resorption is characteristic of osteoporosis, malignant bone disease and inflammatory arthritis. Targeted deletion of Sirtuin1 (Sirt1), a key player in aging and metabolism, in osteoclasts results in increased osteoclast-mediated bone resorption in vivo, making it...

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Detalles Bibliográficos
Autores principales: Gurt, Irina, Artsi, Hanna, Cohen-Kfir, Einav, Hamdani, Gilad, Ben-Shalom, Gal, Feinstein, Ben, El-Haj, Madi, Dresner-Pollak, Rivka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520518/
https://www.ncbi.nlm.nih.gov/pubmed/26226624
http://dx.doi.org/10.1371/journal.pone.0134391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520518/
https://www.ncbi.nlm.nih.gov/pubmed/26226624
http://dx.doi.org/10.1371/journal.pone.0134391

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