Cargando…

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

Increased osteoclast-mediated bone resorption is characteristic of osteoporosis, malignant bone disease and inflammatory arthritis. Targeted deletion of Sirtuin1 (Sirt1), a key player in aging and metabolism, in osteoclasts results in increased osteoclast-mediated bone resorption in vivo, making it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gurt, Irina, Artsi, Hanna, Cohen-Kfir, Einav, Hamdani, Gilad, Ben-Shalom, Gal, Feinstein, Ben, El-Haj, Madi, Dresner-Pollak, Rivka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520518/ https://www.ncbi.nlm.nih.gov/pubmed/26226624 http://dx.doi.org/10.1371/journal.pone.0134391

Ejemplares similares

SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1
por: Thiyagarajan, Ramkumar, et al.
Publicado: (2023)

Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men
por: Artsi, Hanna, et al.
Publicado: (2019)

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
por: Miranda, Melroy X., et al.
Publicado: (2015)

SRT2183 impairs ovarian cancer by facilitating autophagy
por: Sun, Tingting, et al.
Publicado: (2020)

SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice
por: Artsi, Hanna, et al.
Publicado: (2022)

SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease
por: Chao, Chih-Chang, et al.
Publicado: (2022)

Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
por: Nishida, K., et al.
Publicado: (2018)

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers
por: Venkatasubramanian, Sowmya, et al.
Publicado: (2013)

Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation
por: Bai, Xue, et al.
Publicado: (2023)

SUN-033 RNA-Seq Analysis of Ovariectomy-Induced Changes in Mouse Liver Reveals New Targets for Menopause-Associated Metabolic Derangement
por: Stokar, Joshua, et al.
Publicado: (2019)

Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus
por: Noh, Radzi M, et al.
Publicado: (2017)

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
por: Krueger, James G., et al.
Publicado: (2015)

Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway
por: Ye, Tian, et al.
Publicado: (2019)

SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
por: Wiewel, Maryse A, et al.
Publicado: (2013)

Célula ram SRT /
por: Ortega Vargas José Jaime
Publicado: (2002)

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling
por: Zhou, Xiao-Ling, et al.
Publicado: (2014)

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
por: Libri, Vincenzo, et al.
Publicado: (2012)

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis
por: Sands, Bruce E., et al.
Publicado: (2015)

Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus
por: Venkatasubramanian, Sowmya, et al.
Publicado: (2016)

A novel dressing seeded with embryonic artery CD133(+) cells and loaded with the Sirt1 agonist SRT1720 accelerates the healing of diabetic ischemic ulcers
por: Cheng, Pan-Ke, et al.
Publicado: (2018)

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
por: Sung, Jin Young, et al.
Publicado: (2020)

The Hepatokine Adropin Is Regulated by Estrogen
por: Stokar, Joshua, et al.
Publicado: (2021)

Structural Differences between the Streptococcus agalactiae Housekeeping and Pilus-Specific Sortases: SrtA and SrtC1
por: Khare, B., et al.
Publicado: (2011)

Software Process & SRT Configuration Management Tool
por: BUCKHART, Doris
Publicado: (2000)

Role of SrtA in Pathogenicity of Staphylococcus lugdunensis
por: Hussain, Muzaffar, et al.
Publicado: (2020)

CBCT Verification of SRT for Patients With Brain Metastases
por: Papp, Judit, et al.
Publicado: (2022)

Implementation of superficial radiation therapy (SRT) using SRT‐100 Vision™ for non‐melanoma skin cancer in a Radiation Oncology clinic
por: Lee, Yongsook C., et al.
Publicado: (2023)

SRT1720 improves survival and healthspan of obese mice
por: Minor, Robin K., et al.
Publicado: (2011)

An immobilization and localization technique for SRT and IMRT of intracranial tumors
por: Leybovich, Leonid B., et al.
Publicado: (2002)

PTV margin determination in conformal SRT of intracranial lesions
por: Parker, Brent C., et al.
Publicado: (2002)

Algorithms for optoacoustically controlled selective retina therapy (SRT)
por: Seifert, Eric, et al.
Publicado: (2021)

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice
por: Minor, Robin K., et al.
Publicado: (2013)

Treatment accuracy without rotational setup corrections in intracranial SRT
por: Boman, Eeva, et al.
Publicado: (2016)

Telomeres get SIRT-ified
por: Short, Ben
Publicado: (2010)

Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice
por: Stokar, Joshua, et al.
Publicado: (2022)

SIRT1 and SIRT2: emerging targets in neurodegeneration
por: Donmez, Gizem, et al.
Publicado: (2013)

Sirtuin 1 activator SRT2104 protects Huntington's disease mice
por: Jiang, Mali, et al.
Publicado: (2014)

Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma
por: Lian, Wei, et al.
Publicado: (2016)

Directed evolution provides insight into conformational substrate sampling by SrtA
por: Suliman, Muna, et al.
Publicado: (2017)

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model
por: Yu, Linxi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_588qfmqcn41ljd589nv9lahjvg