Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling

Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice leads to impaired synaptic plasticity, suggestive of a role...

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Detalles Bibliográficos
Autores principales: D'Andrea, Ivana, Fardella, Valentina, Fardella, Stefania, Pallante, Fabio, Ghigo, Alessandra, Iacobucci, Roberta, Maffei, Angelo, Hirsch, Emilio, Lembo, Giuseppe, Carnevale, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520656/
https://www.ncbi.nlm.nih.gov/pubmed/25882071
http://dx.doi.org/10.15252/emmm.201404697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520656/
https://www.ncbi.nlm.nih.gov/pubmed/25882071
http://dx.doi.org/10.15252/emmm.201404697

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