Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

The non-obese diabetic mouse model of type 1 diabetes continues to be an important tool for delineating the role of T-cell-mediated destruction of pancreatic β-cells. However, little is known about the molecular mechanisms that enable this disease pathway. We show that insulin reactivity by a CD8(+)...

Descripción completa

Detalles Bibliográficos
Autores principales: Motozono, Chihiro, Pearson, James A., De Leenheer, Evy, Rizkallah, Pierre J., Beck, Konrad, Trimby, Andrew, Sewell, Andrew K., Wong, F. Susan, Cole, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521012/
https://www.ncbi.nlm.nih.gov/pubmed/26085090
http://dx.doi.org/10.1074/jbc.M114.622522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521012/
https://www.ncbi.nlm.nih.gov/pubmed/26085090
http://dx.doi.org/10.1074/jbc.M114.622522

Ejemplares similares