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Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

The non-obese diabetic mouse model of type 1 diabetes continues to be an important tool for delineating the role of T-cell-mediated destruction of pancreatic β-cells. However, little is known about the molecular mechanisms that enable this disease pathway. We show that insulin reactivity by a CD8(+)...

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Detalles Bibliográficos
Autores principales:	Motozono, Chihiro, Pearson, James A., De Leenheer, Evy, Rizkallah, Pierre J., Beck, Konrad, Trimby, Andrew, Sewell, Andrew K., Wong, F. Susan, Cole, David K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521012/ https://www.ncbi.nlm.nih.gov/pubmed/26085090 http://dx.doi.org/10.1074/jbc.M114.622522

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