Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock(Δ19/+) mice contributes to improved glucose homeostasis

Circadian clocks orchestrate essential physiology in response to various cues, yet their mechanistic and functional plasticity remains unclear. Here, we investigated Clock(Δ19/+) heterozygous (Clk/+) mice, known to display lengthened periodicity and dampened amplitude, as a model of partially pertur...

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Detalles Bibliográficos
Autores principales: Jeong, Kwon, He, Baokun, Nohara, Kazunari, Park, Noheon, Shin, Youngmin, Kim, Seonghwa, Shimomura, Kazuhiro, Koike, Nobuya, Yoo, Seung-Hee, Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521189/
https://www.ncbi.nlm.nih.gov/pubmed/26228022
http://dx.doi.org/10.1038/srep12801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521189/
https://www.ncbi.nlm.nih.gov/pubmed/26228022
http://dx.doi.org/10.1038/srep12801

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