Cargando…

Acetaminophen-induced Liver Injury: from Animal Models to Humans

Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whereas progress in understanding rare and unpredictable (idiosyncratic) drug hepatotoxicity is severely hampered by the lack of relevant animal models, enormous insight has been gained in the area of pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaeschke, Hartmut, Xie, Yuchao, McGill, Mitchell R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	XIA & HE Publishing Ltd 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521247/ https://www.ncbi.nlm.nih.gov/pubmed/26355817 http://dx.doi.org/10.14218/JCTH.2014.00014

Ejemplares similares

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury
por: McGill, Mitchell R., et al.
Publicado: (2015)

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange
por: Kennedy, Ryan C, et al.
Publicado: (2019)

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity
por: Xie, Yuchao, et al.
Publicado: (2015)

Biomarkers of mitotoxicity after acute liver injury: Further insights into the interpretation of glutamate dehydrogenase
por: McGill, Mitchell R., et al.
Publicado: (2021)

Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review
por: Ramachandran, Anup, et al.
Publicado: (2023)

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
por: Ramachandran, Anup, et al.
Publicado: (2017)

Acetaminophen-induced apoptosis: Facts versus fiction
por: Jaeschke, Hartmut, et al.
Publicado: (2020)

Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice
por: Knight, Tamara R, et al.
Publicado: (2004)

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
por: Jaeschke, Hartmut, et al.
Publicado: (2022)

Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms
por: Kennon-McGill, Stefanie, et al.
Publicado: (2017)

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity
por: Jaeschke, Hartmut
Publicado: (2022)

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice
por: Sun, Hua, et al.
Publicado: (2021)

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver()
por: Ni, Hong-Min, et al.
Publicado: (2013)

Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation
por: Li, Yuan, et al.
Publicado: (2019)

Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity
por: Jaeschke, Hartmut
Publicado: (2019)

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice
por: Qian, Hui, et al.
Publicado: (2021)

Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
por: Clemens, Melissa M., et al.
Publicado: (2021)

Translational biomarkers of acetaminophen-induced acute liver injury
por: Beger, Richard D., et al.
Publicado: (2015)

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice
por: Wang, Hua, et al.
Publicado: (2019)

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential
por: Du, Kuo, et al.
Publicado: (2016)

Mitochondrial Dynamics in Drug-Induced Liver Injury
por: Ramachandran, Anup, et al.
Publicado: (2021)

Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice
por: Jaeschke, Hartmut, et al.
Publicado: (2022)

The past and present of serum aminotransferases and the future of liver injury biomarkers
por: McGill, Mitchell R.
Publicado: (2016)

Advances in the study of acetaminophen-induced liver injury
por: Li, Xinghui, et al.
Publicado: (2023)

Human Ex-Vivo Liver Model for Acetaminophen-induced Liver Damage
por: Schreiter, Thomas, et al.
Publicado: (2016)

Delayed Administration of N-Acetylcysteine Blunts Recovery After an Acetaminophen Overdose Unlike 4-Methylpyrazole
por: Akakpo, Jephte Y., et al.
Publicado: (2021)

Corrigendum: Advances in the study of acetaminophen-induced liver injury
por: Li, Xinghui, et al.
Publicado: (2023)

Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children
por: McCullough, Sandra, et al.
Publicado: (2020)

Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
por: Ewing, Laura E., et al.
Publicado: (2019)

The impact of sterile inflammation in acute liver injury
por: Woolbright, Benjamin L., et al.
Publicado: (2017)

Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
por: McGill, Mitchell R., et al.
Publicado: (2021)

Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury
por: Pu, Shiyun, et al.
Publicado: (2019)

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy
por: Zhang, Jiaqi, et al.
Publicado: (2020)

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury
por: Schneider, Kai Markus, et al.
Publicado: (2020)

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls
por: Jaeschke, Hartmut, et al.
Publicado: (2021)

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products
por: Liao, Jiaqing, et al.
Publicado: (2023)

Cathelicidin promotes liver repair after acetaminophen-induced liver injury in mice
por: Zhai, Tingting, et al.
Publicado: (2023)

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms
por: Smith, Andrew K., et al.
Publicado: (2020)

Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis
por: Werawatganon, Duangporn, et al.
Publicado: (2014)

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
por: Yan, Mingzhu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9stam2kvo7v2rc357ktfqmc96r