Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain

BACKGROUND: Tau hyperphosphorylation plays a critical role in neurodegenerative diseases [EMBO Mol Med. 6:1142-60, 2014; Annu Rev Neurosci. 24:1121-59, 2001]. Recent evidence has shown that Akt is down-regulated in AD [J Pathol. 225:54-62, 2011]. However, it remained unknown which pathological proce...

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Detalles Bibliográficos
Autores principales: Wang, Long, Cheng, Shanshan, Yin, Zhenyu, Xu, Congyu, Lu, Shuangshuang, Hou, Jinxing, Yu, Tingting, Zhu, Xiaolei, Zou, Xiaoyan, Peng, Ying, Xu, Yun, Yang, Zhongzhou, Chen, Guiquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521471/
https://www.ncbi.nlm.nih.gov/pubmed/26227811
http://dx.doi.org/10.1186/s13024-015-0030-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521471/
https://www.ncbi.nlm.nih.gov/pubmed/26227811
http://dx.doi.org/10.1186/s13024-015-0030-y

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