MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient state promotes MutL homolog recruitment and a...

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Detalles Bibliográficos
Autores principales: Groothuizen, Flora S, Winkler, Ines, Cristóvão, Michele, Fish, Alexander, Winterwerp, Herrie HK, Reumer, Annet, Marx, Andreas D, Hermans, Nicolaas, Nicholls, Robert A, Murshudov, Garib N, Lebbink, Joyce HG, Friedhoff, Peter, Sixma, Titia K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521584/
https://www.ncbi.nlm.nih.gov/pubmed/26163658
http://dx.doi.org/10.7554/eLife.06744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521584/
https://www.ncbi.nlm.nih.gov/pubmed/26163658
http://dx.doi.org/10.7554/eLife.06744

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