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The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres

Dyskeratosis Congenita (DC) is a heritable multi-system disorder caused by abnormally short telomeres. Clinically diagnosed by the mucocutaneous symptoms, DC patients are at high risk for bone marrow failure, pulmonary fibrosis, and multiple types of cancers. We have recapitulated the most common DC...

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Detalles Bibliográficos
Autores principales: Frank, Amanda K., Tran, Duy C., Qu, Roy W., Stohr, Bradley A., Segal, David J., Xu, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521702/
https://www.ncbi.nlm.nih.gov/pubmed/26230315
http://dx.doi.org/10.1371/journal.pgen.1005410