Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles

Enveloped virus vaccines can be damaged by high osmotic strength solutions, such as those used to protect the vaccine antigen during drying, which contain high concentrations of sugars. We therefore studied shrinkage and activity loss of whole inactivated influenza virus in hyperosmotic solutions an...

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Detalles Bibliográficos
Autores principales: Choi, Hyo-Jick, Song, Jae-Min, Bondy, Brian J., Compans, Richard W., Kang, Sang-Moo, Prausnitz, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521748/
https://www.ncbi.nlm.nih.gov/pubmed/26230936
http://dx.doi.org/10.1371/journal.pone.0134431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521748/
https://www.ncbi.nlm.nih.gov/pubmed/26230936
http://dx.doi.org/10.1371/journal.pone.0134431

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