Cis-Acting Sequence Elements and Upstream Open Reading Frame in Mouse Utrophin-A 5'-UTR Repress Cap-Dependent Translation

Utrophin, the autosomal homologue of dystrophin can functionally compensate for dystrophin deficiency. Utrophin upregulation could therefore be a therapeutic strategy in Duchenne Muscular Dystrophy (DMD) that arises from mutation in dystrophin gene. In contrast to its transcriptional regulation, mec...

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Detalles Bibliográficos
Autores principales: Ghosh, Trinath, Basu, Utpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521823/
https://www.ncbi.nlm.nih.gov/pubmed/26230628
http://dx.doi.org/10.1371/journal.pone.0134809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521823/
https://www.ncbi.nlm.nih.gov/pubmed/26230628
http://dx.doi.org/10.1371/journal.pone.0134809

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