Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates

We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1(g609a), and two canonical mutatio...

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Detalles Bibliográficos
Autores principales: Torres, Jessica N, Paul, Lynthia V, Rodwell, Timothy C, Victor, Thomas C, Amallraja, Anu M, Elghraoui, Afif, Goodmanson, Amy P, Ramirez-Busby, Sarah M, Chawla, Ashu, Zadorozhny, Victoria, Streicher, Elizabeth M, Sirgel, Frederick A, Catanzaro, Donald, Rodrigues, Camilla, Gler, Maria Tarcela, Crudu, Valeru, Catanzaro, Antonino, Valafar, Faramarz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522615/
https://www.ncbi.nlm.nih.gov/pubmed/26251830
http://dx.doi.org/10.1038/emi.2015.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522615/
https://www.ncbi.nlm.nih.gov/pubmed/26251830
http://dx.doi.org/10.1038/emi.2015.42

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