Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration

Within the confines of tissues, cancer cells can use blebs to migrate. Eps8 is an actin bundling and capping protein whose capping activity is inhibited by Erk, a key MAP kinase that is activated by oncogenic signaling. We tested the hypothesis that Eps8 acts as an Erk effector to modulate actin cor...

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Detalles Bibliográficos
Autores principales: Logue, Jeremy S, Cartagena-Rivera, Alexander X, Baird, Michelle A, Davidson, Michael W, Chadwick, Richard S, Waterman, Clare M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522647/
https://www.ncbi.nlm.nih.gov/pubmed/26163656
http://dx.doi.org/10.7554/eLife.08314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522647/
https://www.ncbi.nlm.nih.gov/pubmed/26163656
http://dx.doi.org/10.7554/eLife.08314

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