Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

The protein kinase family includes attractive targets for drug development. Methods for screening of kinase inhibitors remain largely limited to in vitro catalytic assays. It has been shown that ATP-competitive inhibitors antagonize interaction between the target kinase and kinase-specific co-chaper...

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Detalles Bibliográficos
Autores principales: Sonamoto, Rie, Kii, Isao, Koike, Yuka, Sumida, Yuto, Kato-Sumida, Tomoe, Okuno, Yukiko, Hosoya, Takamitsu, Hagiwara, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522657/
https://www.ncbi.nlm.nih.gov/pubmed/26234946
http://dx.doi.org/10.1038/srep12728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522657/
https://www.ncbi.nlm.nih.gov/pubmed/26234946
http://dx.doi.org/10.1038/srep12728

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