Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats

Inhibitors of kidney urea transporter (UT) proteins have potential use as salt-sparing diuretics (‘urearetics’) with a different mechanism of action than diuretics that target salt transporters. To study UT inhibition in rats, we screened about 10,000 drugs, natural products and urea analogs for inh...

Descripción completa

Detalles Bibliográficos
Autores principales: Cil, Onur, Esteva-Font, Cristina, Tas, Sadik Taskin, Su, Tao, Lee, Sujin, Anderson, Marc O., Ertunc, Mert, Verkman, A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523423/
https://www.ncbi.nlm.nih.gov/pubmed/25993324
http://dx.doi.org/10.1038/ki.2015.138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523423/
https://www.ncbi.nlm.nih.gov/pubmed/25993324
http://dx.doi.org/10.1038/ki.2015.138

Ejemplares similares