MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

The kinase PINK1 and ubiquitin ligase Parkin can regulate the selective elimination of damaged mitochondria through autophagy (mitophagy). Because of the demand on lysosomal function by mitophagy, we investigated a role for the transcription factor EB (TFEB), a master regulator of lysosomal biogenes...

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Detalles Bibliográficos
Autores principales: Nezich, Catherine L., Wang, Chunxin, Fogel, Adam I., Youle, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523611/
https://www.ncbi.nlm.nih.gov/pubmed/26240184
http://dx.doi.org/10.1083/jcb.201501002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523611/
https://www.ncbi.nlm.nih.gov/pubmed/26240184
http://dx.doi.org/10.1083/jcb.201501002

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