Cargando…

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory role of membrane lipid composition, we combined genetic perturbations of sphingolipid metabolism with the quantification of diverse steps in Tol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Köberlin, Marielle S., Snijder, Berend, Heinz, Leonhard X., Baumann, Christoph L., Fauster, Astrid, Vladimer, Gregory I., Gavin, Anne-Claude, Superti-Furga, Giulio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523684/ https://www.ncbi.nlm.nih.gov/pubmed/26095250 http://dx.doi.org/10.1016/j.cell.2015.05.051

Ejemplares similares

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
por: Heinz, Leonhard X., et al.
Publicado: (2015)

IFITs: Emerging Roles as Key Anti-Viral Proteins
por: Vladimer, Gregory I., et al.
Publicado: (2014)

Crystal structure of mammalian acid sphingomyelinase
por: Gorelik, Alexei, et al.
Publicado: (2016)

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
por: Bigenzahn, Johannes W., et al.
Publicado: (2016)

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking
por: Fauster, Astrid, et al.
Publicado: (2018)

SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
por: Rebsamen, Manuele, et al.
Publicado: (2015)

Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
por: Kropivsek, Klara, et al.
Publicado: (2023)

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
por: Zhang, Xiao-Ou, et al.
Publicado: (2016)

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
por: Essletzbichler, Patrick, et al.
Publicado: (2023)

A circular network of purine metabolism as coregulators of dilated cardiomyopathy
por: Wang, Ge, et al.
Publicado: (2022)

Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis
por: Dori, Martina, et al.
Publicado: (2019)

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
por: Dixon, Scott J., et al.
Publicado: (2015)

Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells
por: Gresle, Melissa M, et al.
Publicado: (2020)

TIAMMAt: Leveraging Biodiversity to Revise Protein Domain Models, Evidence from Innate Immunity
por: Tassia, Michael G, et al.
Publicado: (2021)

Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
por: Fourati, Slim, et al.
Publicado: (2022)

Deep Morphology Learning Enhances Ex Vivo Drug Profiling-Based Precision Medicine
por: Heinemann, Tim, et al.
Publicado: (2022)

dbCNS: A New Database for Conserved Noncoding Sequences
por: Inoue, Jun, et al.
Publicado: (2020)

Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV‐1 pathogenesis
por: Wang, Yetao, et al.
Publicado: (2023)

Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
por: Gaska, Jenna M, et al.
Publicado: (2019)

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
por: Guilliams, Martin, et al.
Publicado: (2022)

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage
por: Zhu, Qifan, et al.
Publicado: (2021)

A circular network of coregulated sphingolipids dictates lung cancer growth and progression
por: Meng, Qiong, et al.
Publicado: (2021)

Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses
por: Andres-Terre, Marta, et al.
Publicado: (2015)

PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry
por: Dey, Sucharita, et al.
Publicado: (2021)

A chromosome-scale epigenetic map of the Hydra genome reveals conserved regulators of cell state
por: Cazet, Jack F., et al.
Publicado: (2023)

A time-resolved molecular map of the macrophage response to VSV infection
por: Kandasamy, Richard K, et al.
Publicado: (2016)

Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature
por: Lombardi, Olivia, et al.
Publicado: (2022)

The coregulator Alien
por: Papaioannou, Maria, et al.
Publicado: (2007)

Cell biology: A key driver of therapeutic innovation
por: Hantschel, Oliver, et al.
Publicado: (2012)

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1
por: Rebsamen, Manuele, et al.
Publicado: (2015)

A structure and evolutionary-based classification of solute carriers
por: Ferrada, Evandro, et al.
Publicado: (2022)

Circular Network of Coregulated Sphingolipids Dictates Chronic Hypoxia Damage in Patients With Tetralogy of Fallot
por: Zhou, Na, et al.
Publicado: (2022)

Global survey of the immunomodulatory potential of common drugs
por: Vladimer, Gregory I., et al.
Publicado: (2017)

Cortisol coregulation in fish
por: Fürtbauer, Ines, et al.
Publicado: (2016)

Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells
por: García-Rodríguez, Juan L., et al.
Publicado: (2023)

Targeting allosteric regulatory modules in oncoproteins: “Drugging the Undruggable”
por: Hantschel, Oliver, et al.
Publicado: (2011)

Conservation and divergence of protein pathways in the vertebrate heart
por: Federspiel, Joel D., et al.
Publicado: (2019)

Systematic Identification, Characterization, and Conservation of Adjacent-Gene Coregulation in the Budding Yeast Saccharomyces cerevisiae
por: Eldabagh, Reem S., et al.
Publicado: (2018)

Evolutionary conservation of sequence motifs at sites of protein modification
por: Li, Shuang, et al.
Publicado: (2023)

Recent advances in combinatorial drug screening and synergy scoring
por: Pemovska, Tea, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_grrk4fnq2hv49i4vmvqubdm3fs