The “Funny” Current (I(f)) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells

Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (I(f)) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases. While IVA inhibits I(f), this effect has been reported...

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Detalles Bibliográficos
Autores principales: Yaniv, Yael, Maltsev, Victor A., Ziman, Bruce D., Spurgeon, Harold A., Lakatta, Edward G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523892/
https://www.ncbi.nlm.nih.gov/pubmed/22777191
http://dx.doi.org/10.3390/molecules17078241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523892/
https://www.ncbi.nlm.nih.gov/pubmed/22777191
http://dx.doi.org/10.3390/molecules17078241

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