Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that leads to widespread motor neuron death, general palsy and respiratory failure. The most prevalent sporadic ALS form is not genetically inherited. Attempts to translate therapeutic strategies have failed because the describ...

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Detalles Bibliográficos
Autores principales: Alves, Chrystian J., Dariolli, Rafael, Jorge, Frederico M., Monteiro, Matheus R., Maximino, Jessica R., Martins, Roberto S., Strauss, Bryan E., Krieger, José E., Callegaro, Dagoberto, Chadi, Gerson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523944/
https://www.ncbi.nlm.nih.gov/pubmed/26300727
http://dx.doi.org/10.3389/fncel.2015.00289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523944/
https://www.ncbi.nlm.nih.gov/pubmed/26300727
http://dx.doi.org/10.3389/fncel.2015.00289

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