Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

OBJECTIVE: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavai...

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Detalles Bibliográficos
Autores principales: Seo, Jae Hong, Park, Jung Bae, Choi, Woong-Kee, Park, Sunhwa, Sung, Yun Jin, Oh, Euichaul, Bae, Soo Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524531/
https://www.ncbi.nlm.nih.gov/pubmed/26251575
http://dx.doi.org/10.2147/DDDT.S87687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524531/
https://www.ncbi.nlm.nih.gov/pubmed/26251575
http://dx.doi.org/10.2147/DDDT.S87687

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