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mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway
The mechanistic target of rapamycin (mTOR) integrates both intracellular and extracellular signals to regulate cell growth and metabolism. However, the role of mTOR signaling in osteoblast differentiation and bone formation is undefined, and the underlying mechanisms have not been elucidated. Here,...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524707/ https://www.ncbi.nlm.nih.gov/pubmed/26241748 http://dx.doi.org/10.1371/journal.pgen.1005426 |