Repression of CD24 surface protein expression by oncogenic Ras is relieved by inhibition of Raf but not MEK or PI3K

CD24 is a dynamically regulated cell surface protein. High expression of CD24 leads to progression of lung, prostrate, colon, and pancreatic cancers, among others. In contrast, low expression of CD24 leads to cell proliferation and metastasis of breast cancer stem cells (BCSCs). Activating mutations...

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Detalles Bibliográficos
Autores principales: Pallegar, Nikitha K., Ayre, D. Craig, Christian, Sherri L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525067/
https://www.ncbi.nlm.nih.gov/pubmed/26301220
http://dx.doi.org/10.3389/fcell.2015.00047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525067/
https://www.ncbi.nlm.nih.gov/pubmed/26301220
http://dx.doi.org/10.3389/fcell.2015.00047

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