Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

AIM2 recognizes foreign dsDNA and assembles into the inflammasome, a filamentous supramolecular signalling platform required to launch innate immune responses. We show here that the pyrin domain of AIM2 (AIM2(PYD)) drives both filament formation and dsDNA binding. In addition, the dsDNA-binding doma...

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Detalles Bibliográficos
Autores principales: Morrone, Seamus R., Matyszewski, Mariusz, Yu, Xiong, Delannoy, Michael, Egelman, Edward H., Sohn, Jungsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525163/
https://www.ncbi.nlm.nih.gov/pubmed/26197926
http://dx.doi.org/10.1038/ncomms8827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525163/
https://www.ncbi.nlm.nih.gov/pubmed/26197926
http://dx.doi.org/10.1038/ncomms8827

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