DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial–mesenchymal transition (EMT) regulators in bre...

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Detalles Bibliográficos
Autores principales: Cho, Min-Hyung, Park, Ji-Hye, Choi, Hee-Joo, Park, Mi-Kyung, Won, Hee-Young, Park, Yeon-Ji, Lee, Chang Hoon, Oh, Seung-Hyun, Song, Young-Soo, Kim, Hyun Sung, Oh, Young-Ha, Lee, Jeong-Yeon, Kong, Gu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525167/
https://www.ncbi.nlm.nih.gov/pubmed/26199140
http://dx.doi.org/10.1038/ncomms8821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525167/
https://www.ncbi.nlm.nih.gov/pubmed/26199140
http://dx.doi.org/10.1038/ncomms8821

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