Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis

Nosiheptide is a parent compound of thiopeptide family that exhibit potent activities against various bacterial pathogens. Its C-terminal amide formation is catalyzed by NosA, which is an unusual strategy for maturating certain thiopeptides by processing their precursor peptides featuring a serine e...

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Detalles Bibliográficos
Autores principales: Liu, Shanshan, Guo, Heng, Zhang, Tianlong, Han, Li, Yao, Pengfei, Zhang, Yan, Rong, Naiyan, Yu, Yi, Lan, Wenxian, Wang, Chunxi, Ding, Jianping, Wang, Renxiao, Liu, Wen, Cao, Chunyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525488/
https://www.ncbi.nlm.nih.gov/pubmed/26244829
http://dx.doi.org/10.1038/srep12744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525488/
https://www.ncbi.nlm.nih.gov/pubmed/26244829
http://dx.doi.org/10.1038/srep12744

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