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Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

BACKGROUND: Despite the prevalence of rhinosinusitis that affects 10%–15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and l...

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Detalles Bibliográficos
Autores principales: Xi, Jinxiang, Yuan, Jiayao Eddie, Si, Xiuhua April, Hasbany, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525801/
https://www.ncbi.nlm.nih.gov/pubmed/26257521
http://dx.doi.org/10.2147/IJN.S87382