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Dynamic Allostery of the Catabolite Activator Protein Revealed by Interatomic Forces
The Catabolite Activator Protein (CAP) is a showcase example for entropic allostery. For full activation and DNA binding, the homodimeric protein requires the binding of two cyclic AMP (cAMP) molecules in an anti-cooperative manner, the source of which appears to be largely of entropic nature accord...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526232/ https://www.ncbi.nlm.nih.gov/pubmed/26244893 http://dx.doi.org/10.1371/journal.pcbi.1004358 |