A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane

Mammalian cytosolic Hsp110 family, in concert with the Hsc70:J-protein complex, functions as a disaggregation machinery to rectify protein misfolding problems. Here we uncover a novel role of this machinery in driving membrane translocation during viral entry. The non-enveloped virus SV40 penetrates...

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Detalles Bibliográficos
Autores principales: Ravindran, Madhu Sudhan, Bagchi, Parikshit, Inoue, Takamasa, Tsai, Billy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526233/
https://www.ncbi.nlm.nih.gov/pubmed/26244546
http://dx.doi.org/10.1371/journal.ppat.1005086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526233/
https://www.ncbi.nlm.nih.gov/pubmed/26244546
http://dx.doi.org/10.1371/journal.ppat.1005086

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