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A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane
Mammalian cytosolic Hsp110 family, in concert with the Hsc70:J-protein complex, functions as a disaggregation machinery to rectify protein misfolding problems. Here we uncover a novel role of this machinery in driving membrane translocation during viral entry. The non-enveloped virus SV40 penetrates...
Autores principales: | Ravindran, Madhu Sudhan, Bagchi, Parikshit, Inoue, Takamasa, Tsai, Billy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526233/ https://www.ncbi.nlm.nih.gov/pubmed/26244546 http://dx.doi.org/10.1371/journal.ppat.1005086 |
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