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Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knockin mice
CBFβ-SMMHC, the fusion protein generated by the chromosome 16 inversion fusion gene, CBFB-MYH11, is known to initiate leukemogenesis. However, the mechanism through which CBFβ-SMMHC contributes to leukemia development is not well understood. Previously it was proposed that CBFβ-SMMHC acts by dominan...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526349/ https://www.ncbi.nlm.nih.gov/pubmed/25742748 http://dx.doi.org/10.1038/leu.2015.58 |