Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study

The tumor suppressor protein p53 can lose its function upon DNA-contact mutations (R273C and R273H) in the core DNA-binding domain. The activity can be restored by second-site suppressor or rescue mutations (R273C_T284R, R273H_T284R, and R273H_S240R). In this paper, we elucidate the structural and f...

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Detalles Bibliográficos
Autores principales: Kamaraj, Balu, Bogaerts, Annemie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526489/
https://www.ncbi.nlm.nih.gov/pubmed/26244575
http://dx.doi.org/10.1371/journal.pone.0134638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526489/
https://www.ncbi.nlm.nih.gov/pubmed/26244575
http://dx.doi.org/10.1371/journal.pone.0134638

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