Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells

Autophagy is a vital pathway for the removal of β-amyloid peptide (Aβ) and the aggregated proteins that cause Alzheimer’s disease (AD). We previously found that cilostazol induced SIRT1 expression and its activity in neuronal cells, and thus, we hypothesized that cilostazol might stimulate clearance...

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Detalles Bibliográficos
Autores principales: Lee, Hye Rin, Shin, Hwa Kyoung, Park, So Youn, Kim, Hye Young, Bae, Sun Sik, Lee, Won Suk, Rhim, Byung Yong, Hong, Ki Whan, Kim, Chi Dae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526537/
https://www.ncbi.nlm.nih.gov/pubmed/26244661
http://dx.doi.org/10.1371/journal.pone.0134486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526537/
https://www.ncbi.nlm.nih.gov/pubmed/26244661
http://dx.doi.org/10.1371/journal.pone.0134486

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