Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway

PURPOSE: To study composition and heterogeneity of insoluble subvisible particles in Mab formulations resulting from degradation of polysorbate 20 and to develop a better understanding of the mechanisms of polysorbate degradation leading to particle formation. METHODS: In this study, we exploit the...

Descripción completa

Detalles Bibliográficos
Autores principales: Saggu, Miguel, Liu, Jun, Patel, Ankit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526581/
https://www.ncbi.nlm.nih.gov/pubmed/25773722
http://dx.doi.org/10.1007/s11095-015-1670-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526581/
https://www.ncbi.nlm.nih.gov/pubmed/25773722
http://dx.doi.org/10.1007/s11095-015-1670-x

Ejemplares similares